Rabs and axonal regeneration

作     者：Cheryl Qian Ying Yong Bor Luen Tang 

作者机构：Department of Biochemistry Yong Loo Lin School of Medicine National University Health System National University of Singapore Graduate School for Integrative Sciences and Engineering National University of Singapore 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第4期

页      面：566-569页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National University of Singapore Graduate School for Integrative Sciences and Engineering(to BLT) 

主　　题：Arf Rab Rab27b axon regeneration axonal transport cortical neurons central nervous system injury membrane trafficking Myosin-V 

摘      要：Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed.