中心周围色素性视网膜炎患者的病程进展

作     者：Sandberg M.A Gaudio A.R Berson E.L 潘佳鸿 

作者机构：Berman-Gund Laboratory Massachusetts Eye and Ear Infirmary 243 Charles Street Boston MA 02114 United States.Dr 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2005年第1卷第12期

页      面：12-12页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：视网膜炎 色素性 视网膜电图 视功能 视标 减退率 

摘      要：PURPOSE: o estimate the mean rates of decline of ocular function in patients with an atypical form of retinitis pigmentosa, termed “ pericentral retinitis pigmentosa. DESIGN: Retrospective observational study. METHODS: setting: Single-center. patient population: Eighteen patients (ages 32 to 65 years) with pericentral retinitis pigmentosa followed for 3 to 26 years. observational procedures: Snellen visual acuity, Goldmann visual field area (V-4e white test light), and full-field electroretinogram (ERG) amplitudes (0.5Hz and 30Hz white flashes). main outcome measures: Mean annual exponential rates of change quantified by repeated-measures longitudinal regression. RESULTS: Estimated mean annual rates of decline of remaining ocular function were 1.2% for visual acuity,1.9% for visual field area, 2.5% for ERG amplitude to 0.5 Hz flashes, and 2.9% for ERG amplitude to 30 Hz flashes. CONCLUSIONS: The mean rates of loss of remaining ocular function of patients with pericentral retinitis pigmentosa were generally slower than those previously reported for patients with typical forms of retinitis pigmentosa.