Myogenic differentiation of mesenchymal stem cells for muscle regeneration in urinary tract

作     者：YANG Bin ZHENG Jun-hua ZHANG Yuan-yuan 

作者机构：Tongji Univ Sch Med Dept Urol Shanghai Peoples Hosp 10 Shanghai 200072 Peoples R China Wake Forest Univ Sch Med Wake Forest Inst Regenerat Med Winston Salem NC 27101 USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第15期

页      面：2952-2959页

核心收录：

学科分类：0710[理学-生物学] 0821[工学-纺织科学与工程] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 082101[工学-纺织工程] 090102[农学-作物遗传育种] 

基　　金：grants from the National Natural Science Foundation of China Specialized Research Fund for the Doctoral Program of Higher Education in China 

主　　题：mesenchymal stem cell tissue engineering regenerative medicine bladder stress urinary incontinence 

摘      要：Objective This article was to review the current status of adult mesenchymal stem cells transplantation for muscle regeneration in urinary tract and propose the future prospect in this field. Data sources The data used in this review were mainly obtained from articles listed in Medline and PubMed （2000- 2013）. The search terms were ＂mesenchymal stem cells＂, ＂bladder＂, ＂stress urinary incontinence＂ and ＂tissue engineering＂. Study selection Articles regarding the adult mesenchymal stem cells for tissue engineering of bladder and stress urinary incontinence were selected and reviewed. Results Adult mesenchymal stem cells had been identified and well characterized in human bone marrow, adipose tissue, skeletal muscle and urine, and demonstrated the capability of differentiating into smooth muscle cells and skeletal muscle ceils under myogenic differentiation conditions in vitro. Multiple preclinicat and clinical studies indicated that adult mesenchymal stem cells could restore and maintain the structure and function of urinary muscle tissues after transplanted, and potentially improve the quality of life in patients. Conclusions Smooth or skeletal myogenic differentiation of mesenchymal stem cells with regenerative medicine technology may provide a novel approach for muscle regeneration and tissue repair in urinary tract. The long-term effect and safety of mesenchymal stem cell transplantation should be further evaluated before this approach becomes widely used in patients.