Efficient Synthesis of the Functionalized Spiro[indoline-3,4＇-pyridine] via Four-component Reaction

作     者：孙晶 吴群 张藜娟 颜朝国 

作者机构：College of Chemistry&Chemical EngineeringYangzhou UniversityYangzhouJiangsu 225002China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2012年第30卷第7期

页      面：1548-1554页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/cjoc.201100657 or from the author.Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 21172189) 

主　　题：spiro compound isatin multicomponent reaction electron-deficient alkyne 1,4-dihydropyridine 

摘      要：An efficient synthetic procedure for the functionalized spiro[indoline-3,4＇-pyridine] was developed via the four-component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity.