Assessment of the Clinical Effect of Chinese Medicine Therapy Combined with Psychological Intervention for Treatment of Patients of Peri-menopausal Syndrome Complicated with Hyperlipidemia

作     者：钱丽旗 王玢 牛京育 高珊 赵丹阳 

作者机构：Department of Traditional Chinese MedicineFirst Affiliated Hospital of General Hospital of PLA General Hospital of Air Force Area of Beijing Chaoyang Hospital Beijing Yongding Road Hospital 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2010年第16卷第2期

页      面：124-130页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 100509[医学-中医妇科学] 1002[医学-临床医学] 10[医学] 

主　　题：Chinese medicine therapy psychological intervention peri-menopausal syndrome blood lipid sex hormone 

摘      要：Objective：To observe the effect of Chinese medicine therapy combined with psychological intervention（combined therapy） on the clinical symptoms and levels of blood lipids and sex hormones of patients of peri-menopausal syndrome complicated with ***：With the use of a randomizing digital table method,185 patients that fit the registration standard were randomly assigned to three *** 59 cases in Group A were treated with two Chinese patents,Kunbao Pill（坤宝丸） and Modified Xiaoyao Pill（加味逍遥丸）;the 63 in Group B received psychological intervention alone;and the 63 in Group C were treated with both（the combined therapy）,with the treatment course for all six *** items of observation included： （1） scoring by SCL-90 on eight factors and seven symptoms;（2） scoring on Chinese medicine symptoms by Kupermann scale,including anxiety and bad temper,scorching sense ation with sweating,dizziness,tinnitus, soreness and weakness of the loin and knees,palpitation,insomnia,lassitude,weakness,and hyposexuality; （3） blood contents of total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）,apoprotein Al（ApoAl） and B（ApoB）;（4） levels of sex hormones, including estradiol（E_2）,progesterone（P）,pituitary prolactin（PRL）,follicular stimulating hormone（FSH）,and luteinzing hormone（LH） in some randomly selected patients;（5） adverse reaction;and（6） one-year follow-up study on long-term ***：A total of 21 patients（6,8,and 7 cases in Groups A,B,and C,respectively） dropped out;the drop-out rate was insignificant among groups.（1） The markedly effective rates in Group A, B,and C were 26.42%（14/53）,18.18%（10/55）,and 53.57%（30/56）,respectively,and the total effective rates in them were 64.15%（34/53）,50.91%（28/55）,and 87.50%（49/56）,respectively,suggesting the therapeutic efficacy in Group C was significantly better than that in Groups A and B（P〈0.01）.（2） SCL-90 scoring showed that the total scores d