Enantiomeric separation of α-phenylethylamine and its analogs by mixed chiral and achiral stationary phase
Enantiomeric separation of α-phenylethylamine and its analogs by mixed chiral and achiral stationary phase作者机构：Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116012 China Department of Chemistry Fujian Quanzhou Teacher's College Quanzhou Pujian 363000 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：1996年第14卷第4期
页 面：348-353页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学]
基 金：Project supported by the National Natural Science Foundation of China
主 题：Modified cyclodextrin enantiomeric separation,α-phenylethylamine and its analogs
摘 要：A mixed stationary phase of modified β-cyclodextrin, 2,6-di-O-butyl-3-O-butyryl-β-cyclodextrin (phase A), and SE-54 (phase B) was used for enantiomeric separation of α-phenylethylami-ne, o,m,p-methyl and o,m,p-methoxy-substituted analogs. The composition of mixed phase was selected by comparison of each calculated amin(= (γm,i+1)/(γm,i)) the relative retention values of the most adjacent peaks, and γm,last, the relative retention values of the last eluting peak at each preselected ratio. Values of γm,i,α calculated by derived equations were in good agreement with the experimental results obtained with two specified mixed phases. All solutes investigated were almost baseline separated at a predicted composition of phase A and phase B in a single run within 18 minutes.
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