Application of adult stem cells in neural tissue engineering

作     者：Lihong Piao Wei Wang 

作者机构：Liaoning Medical University Jinzhou 121001 Liaoning Province China Jinzhou CentralHospital Jinzhou 121000 Liaoning Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2006年第1卷第6期

页      面：557-559页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：创伤 神经系统/治疗 干细胞移植 综述 组织工程 人类 

摘      要：OBJECTIVE： To investigate the progress in finding, isolation and culture, proliferation and differentiation, and application in neural tissue engineering of adult stem cells （ASCs）. DATA SOURCES ： Using the terms ＂adult stem cells, nerve, tissue engineering＂, we searched the PubMed for adult stem calls-related studies published in English from January 2001 to August 2006. Meanwhile, we also performed a China National Knowledge Infrastructure （CNKI） search for homochronous correlative literatures on the computer by inputting the terms ＂adult stem cells, nerve, tissue engineering＂in Chinese. STUDY SELECTION ： The materials were firstly selected. Studies related to ASCs were involved and their full texts were searched for. Inclusive criteria： （1） Literatures about the sources, distribution, culture, proliferation and differentiation, and application in the repair of neural ASCs by tissue engineering. （2）Articles recommended either by randomized, blind or by other methods were not excluded. Exclusive criteria： （1）Embryonic stem cells. （2） Review, repetitive study, case report, Meta analysis. DATA EXTRACTION： Totally 1 278 articles related to ASCs were collected, 32 were involved and the other 1 246 were excluded. DATA SYNTHESIS ： Adult stem cell has the ability of self-renewal, unceasing proliferation and transdifferentiation. It has wide source, which does not involved in ethical problems. It has advantages over embryonic stem cell. Studies on the isolation and culture, induction and differentiation and application in neural ASCs by tissue engineering contribute to obtaining considerable ASCs, so as to provide experimental and theoretical bases for the application of ASCs in repairing nerve injury in clinical practice. CONCLUSION ： ASCs play a very important role in neural tissue engineering