YKL-40 expression in human hepatocellular carcinoma:a potential biomarker?

作     者：Tarek Hassanein 

作者机构：Liver CenterHillcrest Medical CenterUniversity of California at San DiegoCA 92103USA 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2011年第10卷第6期

页      面：605-610页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a grant from the National Natural Science Foundation of China (No. 81072035) 

主　　题：YKL-40 hepatocellular carcinoma cirrhosis 

摘      要：BACKGROUND:YKL-40 is a new biomarker with diagnostic value in many different *** it may serve as a biomarker for hepatocellular carcinoma (HCC) is still *** study aimed to examine the expression of YKL-40 in the serum and liver tissues of HCC patients and in HCC cell lines,in comparison with that in non-HCC liver disease patients and non-tumor hepatic cell lines,***:Immunohistochemical staining was used to detect YKL-40 protein expression in liver biopsy specimens from 8 HCC *** was used to assess the serum YKL-40 level in 90 HCC patients,90 inactive HBsAg carrier (IHC) patients with normal liver functions,and 90 liver cirrhosis ***-time PCR was used to determine the YKL-40 mRNA expression in three HCC cell lines and two non-tumor hepatic cell ***:Immunohistochemical staining of liver biopsy specimens from HCC patients showed that the YKL-40 protein expression in tumor tissue was higher than that in adjacent normal *** revealed that the YKL-40 serum level in the HCC group was significantly higher than that in the IHC group,but not significantly different from that in the cirrhosis ***-time PCR showed that YKL-40 mRNA levels in HCC cell lines were significantly higher than those in nontumor hepatic ***:YKL-40 is highly expressed in HCC at the molecular,cellular and tissue ***,it may not serve as a serum biomarker for HCC because measurement of the serum YKL-40 level cannot distinguish HCC from cirrhosis.