Effects and Mechanism of Irbesartan on Tubulointerstitial fibrosis in 5/6 Nephrectomized Rats

作     者：赵刚 赵洪 凃玲 徐西振 郑常龙 姜美华 汪培华 汪道文 

作者机构：The Institute of Hypertension and Cardiovascular DivisionDepartment of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Geriatric MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2010年第30卷第1期

页      面：48-54页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by a grant from Natural Sciences Foundation of Hubei Province China(No.2008CDB178) 

主　　题：chronic tubulointerstitial fibrosis irbesartan 5/6 nephrectomy signaling pathway 

摘      要：Tubulointerstitial fibrosis(TIF)is a common pathological feature of end-stage kidney *** studies showed that upregulation of TGFβ1 notably contributed to the chronic renal injury and irbesartan halted the development of TIF in rats with 5/6 renal mass *** study was to investigate the effects of irbesartan on chronic TIF and the mechanism involved TGFβ1 in the rodent model of chronic renal failure involving 5/6 *** results showed that irbesartan significantly attenuated th...