局部使用5-氨基-γ-酮戊酸联合强脉冲光照治疗光老化

作     者：Dover J.S Bhatia A.C Stewart B Arndt K.A 李晓莉 

作者机构：SkinCare Physicians 1244 Boylston St Chestnut Hill MA 02467 United States.Dr 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第1期

页      面：29-30页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：光老化 强脉冲光 光照治疗 戊酸 色素沉着斑 预治疗 点状色素沉着 光损伤 满意度评分 细纹 

摘      要：Background: The adjunctive use of 5-aminolevulinic acid (5-ALA) with intense pulsed-light (IPL) treatments has been suggested to increase the benefit of IPL for photoaging; however, to our knowledge, no controlled trials have been performed. Design: A prospective, randomized, controlled, split-face study was designed. Twenty subjects participated in a series of 3 split-face treatments 3 weeks apart in which half of the face was pretreated with 5-ALA followed by IPL treatment while the other half was treated with IPL alone. Two additional full-face treatments (with IPL alone) were then delivered 3 weeks apart. Assessment of global photodamage, fine lines, mottled pigmentation, tactile roughness, and sal lowness (on a scale of 0-4) was performed by a blinded investigator before each treatment and 4 weeks after the final treatment. Patients also completed an ass essment at the conclusion of the study comparing their results with pretreatment photographs. Results: All 20 volunteers completed the study. Pretreatment with 5-ALA resulted in more improvement in the global score for photoaging (16 [80 %] subjects vs 9 [45%] subjects;P=.008) and mottled pigmentation (19 [95%] subjects vs 12 [60%] subjects; P=.008) than IPL treatment alone. More successful results were achieved on the side pretreated with 5-ALA compared with the side tr eated with IPL alone for fine lines (12 [60%] subjects vs 5 [25%] subjects ; P=.008) and mottled pigmentation (17 [85%] subjects vs 4 [20%] subjects; P .001). While there was noticeable improvement over baseline scores with respect to tactile roughness and sallowness, pretreatment with 5-ALA did not seem to enhan ce the results of the IPL treatment. The final investigator cosmetic evaluations (P=.0002) and subject satisfaction scores (P=.005) were significantly better fo r the 5-ALA-pretreated side. Both treatments were well tolerated, with little difference in the incidence or profile of adverse effects with or without 5-ALA pretreatment. Co