输卵管闭锁和积水患者的子宫内膜α1和β3细胞整联蛋白亚单位的表达

作     者：Savaris R.F. Pedrini J.L. Flores R. 张旸 

作者机构：Universidade Federal Do Rio Grande Do Sul Servico de Ginecologiae Obstetrcia Rua RaminoBarcelos 2350/1125 Porto Alegre RS 90035-003 Brazil Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第4期

页      面：33-33页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：输卵管闭锁 子宫内膜 亚单位 整联蛋白 植入窗口期 免疫组化分析 不孕原因 腹腔镜诊断 组织学评分 

摘      要：Objective: To determine the expression of α1 and β3 integrin subunit on the endometrium of infertile patients with hydrosalpinx and infertile patients with tubal phimosis. Design: Case-control study. Setting: Tertiary medical center. Patient( s): Infertile patients with radiologic or laparoscopic diagnosis of hydrosalpinx (n = 11) or tubal phimosis (n = 12) as the only cause of infertility, and fertile controls (n = 17). Intervention(s): Immunohistochemical analysis of α1 and β3 integrin subunits was performed on endometrial biopsies obtained during the implantation window. Main Outcome Measure(s): Histologic score (HSCORE) on luminal and glandular endometrium of the patients with hydrosalpinx or tubal phimosis and the normal fertile controls. Result(s): The median (±SEM) HSCORE for β3 subunit expression in endometrial glands was 0.39 ±0.23 and 0.42 ±0.18 for tubal phimosis and hydrosalpinx, respectively, and 1.74 ±0.26 for fertile controls. The median HSCORE for β3 subunit expression in luminal epithelium for tubal phimosis, hydrosalpinx, and fertile controls was 0.07 ±0.06, 0.21 ±0.18, and 1.03 ±0.31, respectively. No statistical difference was observed on the expression of α1 integrin subunit expression between the three groups. Conclusion(s): The endometrial expression of β3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation.