Cathodic adsorptive stripping voltammetry of an anti-emetic agent Granisetron in pharmaceutical formulation and biological matrix

作     者：Rajeev Jain Ramkishor Sharma 

作者机构：School of Studies in Chemistry Jiwaji University 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2012年第2卷第6期

页      面：443-449页

学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学] 

基　　金：The authors are thankful to Veeda Clinical Research Pvt. Ltd.  Ahmedabad kindly providing the standard of Granisetron 

主　　题：Granisetron Human plasma Solid-phase extraction Pharmaceuticalformulation Voltammetry Hanging mercury dropelectrode 

摘      要：Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode （HMDE） in the potential range from -1.3 to -1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 5-200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50-225 ng/mL with detection limit 11.75 ng/mL.