Synthesis of cyclopentenyl and cyclohexenyl ketones via [3 + 2] and [4 + 2] annulations of 1,2-allenic ketones

作     者：Liang-Yan Cui Sheng-Hai Guo Bin Li Xin-Ying Zhang Xue-Sen Fan 

作者机构：School of Chemistry and Chemical EngineeringKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Key Laboratory for Environmental Pollution ControlHenan Normal University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第1期

页      面：55-57页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(Nos.21172057,21272058) the Research Fund for the Doctoral Program of Higher Education(No.20114104110005)forfinancial support 

主　　题：Cyclopentenylketone Cyclohexenyl ketone 1 2-Allenic ketone Phosphine-catalyzed annulation 

摘      要：In this paper, an efficient synthesis of cyclopentenyl ketones and cyclohexenyl ketones through tertiary phosphine catalyzed [3 ＋ 2] and [4 ＋ 2] annulations of 1,2-allenic ketones with activated alkenes has been developed. Compared with published synthetic methods on cyclopentenyl ketones and cyclohexenyl ketones, the protocols developed in this paper have the advantages such as readily available starting materials, mild reaction conditions and high efficiency.