Evaluation of the wound healing potential of isoquercetin-based cream on scald burn injury in rats
作者机构：Pharmacology Research LaboratoryDepartment of PharmacologyKhalsa College of PharmacyAmritsarIndia. Department of PharmaceuticalAnalysisKhalsa College of PharmacyAmritsarIndia. Department ofBiochemistryKhalsa College of Pharmacy and TechnologyAmritsarIndia.
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2016年第4卷第1期
页 面：45-52页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Isoquercetin Scald Burn Free radicals Wound healing
摘 要：Background:The present study was designed to evaluate the potential of isoquercetin-based cream formulation on scald burn wound injury in ***:Four isoquercetin-based cream formulations viz.0.01,0.02,0.04,and 0.06%w/w were *** base and standard anti-burn cream containing silver sulfadiazine were also used for *** burn was given to rats by pouring water at 90℃on a shaved dorsal area of 20 *** second-degree burn injury was produced which was evaluated for the next 21 days for the percentage of wound contraction and period of *** day 21,the rats were sacrificed and histopathological slides were prepared using hematoxylin-eosin *** tissue was also screened for levels of oxidative stress using thiobarbituric acid reactive species(TBARS)and reduced glutathione(GSH)***:There was a significant increase in the percentage of wound contraction and a significant decrease in the period of epithelialization in isoquercetin-based cream-treated groups as compared with the control ***,most significant results were obtained with isoquercetin 0.06%w/w *** y,isoquercetin 0.06%w/w cream treatment resulted in almost complete re-epithelialization and re-structuring of the wound *** was a significant rise in TBARS and a decrease in GSH levels in the burn injury group which was reversed to a major extent by the application of isoquercetin-based ***:The results indicate the wound healing potential of isoquercetin-based *** biochemical studies indicate towards a possible role of free radical scavenging in the observed effects of isoquercetin in wound healing.
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