妊娠早期血浆低HLA-G蛋白水平预示先兆子痫
Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy作者机构：790 Bay Street Toronto Ont. M5G 1N8 Canada Dr.
出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)
年 卷 期：2005年第1卷第11期
页 面：10-11页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：妊娠早期 HLA-G蛋白 先兆子痫 早期预测 研究设计
摘 要：Objective: The aim of this study was to determine whether circulating HLA-G levels, early in pregnancy, predict the subsequent development of preeclampsia (PE). Study design: Plasma samples, collected longitudinally during the first, second, and third trimesters, from 12 PE patients and 12 matched control patients were tested for HLA-G protein using a validated sandwich ELISA. Results: First and second trimester HLA-G levels in PE were significantly lower than in control patients (first trimester, 1.25 μ g/mL vs 1.95 μ g/mL, P = .029; second trimester, 1.11 μ g/mL vs 1.90 μ g/mL, P = .024). Conclusion: Our results indicate that HLA-G levels in plasma from women who subsequently develop PE are lower than control patients, as early as the first trimester. This suggests that determination of circulating HLA-G protein concentration may be useful as an early predictor for the development of PE.
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