Synthesis and Characterization of a Novel Galactosylated Cholesterol

作     者：Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN 

作者机构：School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 School of Pharmcy Yantai University Yantai 264005 Shandong Engineering Research Center of Natural Drugs Yantal 264003 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第2期

页      面：173-176页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Galactosylated cholesterol (5-cholesten-3-yl)-4-oxo-4-[2-(lactobionylamido)ethylamido]butanoate hepatocyte-selective targeting doxorubicin. 

摘      要：A novel galactosylated cholesterol with mono-galactoside moiety, （5-cholesten-3-yl）-4-oxo-4-[2-（lactobionylamido）ethylamido]butanoate 6 was synthesized. Its chemical structure was characterized by IR, ESI-MS, ^13C NMR, ^1H NMR. Doxorubicin entrapped in the liposomes containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymal cells in mice.