In vitro Visualization and Characterization of Receptors for Vasoactive Intestinal Peptide, Secretin and Somatostatin in Colon Cancer
作者机构：DeptofGastroenterologyTheFirstHospitalChongqingUniversityofMedicalSciencesChongqingChina Dept.ofGastroenterology-HepatologyLeidenUniversityMedicalCenterLeidenTheNetherlands
出 版 物：《胃肠病学》 (Chinese Journal of Gastroenterology)
年 卷 期：2000年第5卷第B8期
页 面：80-80页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：受体 血管活性 肠内疾病 缩氨酸 分泌素 生长激素抑制素 结肠癌 肿瘤
摘 要：Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the development and metastasis of colorectal cancer. This study visualized and characterized the receptors for vasoactive intestinal peptide, secretin and somatostatin in the development and metastasis of colorectal cancer with storage phosphor autoradiography. Receptors for these three peptides were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of vasoactive intestinal peptide receptors was shown in the sequence from tumor-free colon (Kd=0.93nmol),
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