离体人类脐静脉中的缓激肽B1受体:体外调控过程的实验模型（英文）

作     者：Sergio Pablo SARDI,Andrea Emilse ERRASTI,Verónica REY-ARES,María Pía ROGINES-VELO,Rodolfo Pedro ROTHLIN 

作者机构：Departamento de Farmacología Facultad de Medici-na Universidad de Buenos Aires Paraguay 2155 Piso 15 1121 Buenos Aires Argentina Departamento de Farmacología Facultad de Medici-na Universidad de Buenos Aires Paraguay 2155 Piso 15 1121 Buenos Aires Argentina Departamento de Farmacología Facultad de Medici-na Universidad de Buenos Aires Paraguay 2155 Piso 15 1121 Buenos Aires Argentina Departamento de Farmacología Facultad de Medici-na Universidad de Buenos Aires Paraguay 2155 Piso 15 1121 Buenos Aires Argentina Departamento de Farmacología Facultad de Medici-na Universidad de Buenos Aires Paraguay 2155 Piso 15 1121 Buenos Aires Argentina 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2000年第2期

页      面：11-16页

核心收录：

学科分类：10[医学] 

主　　题：缓激肽 脐静脉 上调(生理学) NF-κB 

摘      要：Bradykinin (BK) B1 receptors are not normally expressed in physiological conditions but could be induced in immunopathological states. Molecular approaches have confirmed that BK B1 receptor gene is transcription-ally induced in injured tissues. In these situations, the cytokine network and other proinflammatory mediators are close linked to BK B1 receptor *** this article, we describe the functional characterization of the BK B1 receptor up-regulation process in the isolated human umbilical vein and the pharmacological tools employed to demonstrate the de novo synthesis of these receptors. BK B1 receptors are up-regulated in a time- and protein synthesis-dependent process. Furthermore, in this tissue we have demonstrated the close link between the BK B1 receptor sensitization and proinflammatory cytokines, such as interleukin-1 beta and tumor necrosis factor-alpha. We also discuss the possible relationship between nuclear factor-kappa B and BK B1 receptor induction in human umbilical vein.