Clinical features of solitary necrotic nodule of the liver

作     者：Zhou, Yan-Ming Li, Bin Xu, Feng Wang, Bin Li, Dian-Qi Liu, Peng Yang, Jia-Mei 

作者机构：Second Mil Med Univ Eastern Hepatobiliary Surg Hosp Dept Special Treatment Shanghai 200438 Peoples R China Second Mil Med Univ Eastern Hepatobiliary Surg Hosp Dept Pathol Shanghai 200438 Peoples R China Fujan Med Univ Xiamen Hosp 1 Dept Hepatobiliary Pancreato Vasc Surg Xiamen 361003 Peoples R China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2008年第7卷第5期

页      面：485-489页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：liver neoplasm solitary necrotic nodule 

摘      要：BACKGROUND: Solitary necrotic nodule of the liver is a rare nonmalignant lesion. The present study aimed to clarify the clinical features of the disease. METHOD: The medical records of 51 patients with histologically confirmed solitary necrotic nodule of the liver who received surgical resection at our institution were retrospectively reviewed. RESULTS: Solitary necrotic nodule of the liver was found mainly in males (68.6%, 35/51), and patients ranged in age from 5 to 69 years with a mean of 45.3. Most of the patients (72.5%) had no significant symptoms, with negative results for the serum tumor markers alpha-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonic antigen. The mean diameter of the nodule was 23 mm (range 10-55 mm). Compared with ultrasonographic and computed tomography findings, the specific features of magnetic resonance imaging were more helpful for differential diagnosis of the disease. CONCLUSIONS: Solitary necrotic nodule of the liver is a rare nonmalignant lesion, showing no notable symptoms and potential complications. The pathological change of the disease is not significant over a lifetime. Conservative treatment and clinical follow-up are recommended.