Antidiabetic activity of methanolic bark extract of Alhizia odoratissima *** alloxan induced diabetic albino mice

作     者：Dinesh Kumar Sunil Kumar Sonia Kohli Renu Arya Jyoti Gupta 

作者机构：Institute of Pharmaceutical SciencesKurukshetra UniversityKurukshetra-136119HaryanaIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第11期

页      面：900-903页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Herbal Nature Park National Institute of Information and Communications Technology, (NISCAIR/RHM 1382/184) 

主　　题：Albizia odoratissima Antidiabetic potential Methanolic extract Alloxan Mice 

摘      要：Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima *** in alloxan induced diabetic ***:Group-Ⅰ(normal control) mice received only basal diet without any *** Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard ***-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,***:The results of the study indicates that Albizia odoratissima bark extract significantly(P0.01) reduced the blood sugar *** bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic ***: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals.