胰腺转移癌:对22例患者的多中心研究

作     者：Moussa A. Mitry E. Hammel P. G. Lesur 赵天智 

作者机构：Serv. Hepato Gastroenterol./O. D. H.opital Ambroise Paré 92104 Boulogne Billancourt France 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第3期

页      面：29-30页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：肾细胞癌 结直肠癌 原发肿瘤 平均生存期 手术切除术 外科手术患者 组织学诊断 平均间隔 低回声肿块 黑色素瘤 

摘      要：Aims of the study To evaluate the diagnosis, treatment and outcome of patients with pancreatic metastases. Patients and methods We retrospectively reviewed the records of patients with pancreatic metastasis managed in the Paris area between 1990 and 2000. Results The series analyzed included 22 patients, 10 men and 12 women, mean age 61 years (range: 35-76). The primary tumors were renal cell carcinoma (N = 10), colorectal cancer (N = 4), lung cancer (N = 4), breast cancer (N = 2), cutaneous melanoma (N = 1) and ileal carcinoid (N = 1). The mean interval between primary treatment and presentation was 73.5 months (range: 2-151). Diagnosis was established because of clinical symptoms (N = 15) or during surveillance (N = 7). Computed tomography (N = 19) and endoscopie ultrasound (EUS) (N= 18) mainly showed solitary and hypodense/or hypoechoic masses. Histological diagnosis was obtained before surgery by EUS guided fine needle aspiration(N =6), ultra sound guided biopsy (N = 3) or duodenoscopy (N = 3). Among 10 patients with primary renal cell carcinoma, 7 were treated by surgery. Median global survival was 33 months. Median survival was 61 months in the event of surgical treatment and 20 months in the other patients (ns). Mean survival depended on the type of primary tumor, 61 months for renal cell carcinoma and 33 for colorectal cancer (P = 0.06). Conclusions Most pancreatic metastases develop from renal cell carcinoma and can occur several years after nephrectomy. Histological diagnosis is often obtained before surgery. Surgical resection must be discussed as it can allow long term survival.