先天性全盲患者舌部电触觉刺激显示交叉式可塑性

作     者：Ptito M. Moesgaard S.M. Gjedde A. Kupers R. 郭俊 

作者机构：School of Optometry Université de Montréal CP 6128Montreal Que. H3C 3J7 Canada 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第8期

页      面：13-14页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：触觉刺激 全盲 交叉式 可塑性变化 rCBF 局部脑血流量 顶叶皮层 检测任务 视觉皮层 枕区 

摘      要：In sensory substitution, information acquired with one sensory modality is use d to accomplish a task which is normally subserved primarily by another sensory modality. We used PET to study cross-modal plasticity in the congenitally blind , using electrotactile stimulation of the tongue. Blind (n=6) and sighted blindfolded controls (n=5) were scanned before and after they were trained to use their tongue in a Snellen orientation detect ion task. Results showed that both groups of subjects learned the discrimination orientation task after seven 1 h training sessions. Before training, no signifi cant changes in regional cerebral blood flow (rCBF) were observed in the occipit al cortex in either group. In sharp contrast, activity in the occipital cortex i ncreased after practice for the blind, but not for the sighted, providing eviden ce for training-induced plasticity in the blind. An inter-regional correlation analysis showed that task-related rCBF changes in left posterior parietal cort ex were positively correlated with rCBF changes in the occipital area of the tra ined blind. These data reveal that cross-modal plasticity in the blind develops rapidly and that the occipital cortex is part of a functional neural network fo r tactile discrimination in conjunction with the posterior parietal cortex. Our data further show that the tongue can act as a portal to convey somatosensory in formation to visual cortex.