Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology

作     者：Heather Bowling Aditi Bhattacharya Eric Klann Moses V.Chao 

作者机构：Center for Neural ScienceNew York University Center for Brain Development and RepairInstitute for Stem Cell Biology and Regenerative Medicine Departments of Cell BiologyPhysiologyand Neuroscience and PsychiatryKimmel Center for Biology and Medicine at the Skirball InstituteNew York University School of Medicine 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第3期

页      面：363-367页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by NIH grants NS034007 and NS047384 supported by NIH grants NS21072,and HD23315 supported by funds from the Department of Biotechnology,Government of India and the Shanta Wadhwani Foundation 

主　　题：BONLAC BDNF adult slice proteomics neuroproteomics SILAC BONCAT hippocampus proteinsynthesis 

摘      要：Brain-derived neurotrophic factor（BDNF） plays an important role in neurodevelopment,synaptic plasticity,learning and memory,and in preventing *** decades of investigations into downstream signaling cascades and changes in cellular processes,the mechanisms of how BDNF reshapes circuits in vivo remain *** informational gap partly arises from the fact that the bulk of studies into the molecular actions of BDNF have been performed in dissociated neuronal cultures,while the majority of studies on synaptic plasticity,learning and memory were performed in acute brain slices or in vivo.A recent study by Bowling-Bhattacharya et al.,measured the proteomic changes in acute adult hippocampal slices following treatment and reported changes in proteins of neuronal and non-neuronal origin that may in concert modulate synaptic release and secretion in the *** this paper,we place these findings into the context of existing literature and discuss how they impact our understanding of how BDNF can reshape the brain.