Factors influencing the presence of circulating differentiated thyroid cancer cells in the thyroidectomy perioperative period

作     者：Wentao Wei Qinjiang Liu Wei Yao 

作者机构：Department of Head and Neck SurgeryThe Cancer Hospital of Gansu Province 

出 版 物：《Oncology and Translational Medicine》 (肿瘤学与转化医学（英文版）)

年 卷 期：2015年第1卷第5期

页      面：208-211页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by a grant from the Gansu Province Key Traditional Chinese Medicine Project(No.GZK-2010-Z9) 

主　　题：thyroid cancer flow cytometry circulating tumor cell 

摘      要：Objective The aim of the study was to detect circulating differentiated thyroid cancer （DTC） micrometas-tasis and to investigate the factors influencing their presence in the perioperative thyroiclectomy period. Methods DTC micrometastases in the peripheral blood were detected with flow cytometry, and patient clinical and pathological factors were analyzed in 327 DTC patients. Results Circulating blood micrometastases were present in the peripheral circulation at a higher rate 1 week postoperatively than preoperatively and at 4 weeks postoperatively （P 〈 0.05）. The preoperative pres- ence of circulating micrometastasis was associated with the size of the tumor and the presence of lymph node metastasis （P 〈 0.05）, but was not related to the degree of tumor differentiation （P 〉 0.05）. At 4 weeks postoperatively, the presence of circulating micrometastasis was not associated with tumor size or lymph node stage （P 〉 0.05）, but was associated with poorly differentiated tumors （P 〈 0.05）. Conclusion The presence of circulating DTC micrometastases correlates to tumor size, lymph node stage, and operative manipulation. The differentiation degree of the tumors were associated with the persistent presence of micrometastasis in the circulating blood.