Determination of Epinephrine Using Poly(Neutral Red)Modified Carbon Fibre Microelectrodes by Anodic Stripping Voltammetry

作     者：Tang Xiaorong, Sun Yuanxi, Yao Bing, He Fei, Zhou Xingyao Department of Chemistry, Wuhan University, Wuhan 430072, China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：1997年第2卷第4期

页      面：97-101页

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 0401[教育学-教育学] 04[教育学] 07[理学] 

主　　题：carbon fibre microelectrode poly(neutral red) epinephrine anodic stripping voltammetry 

摘      要：Poly(neutral red) film modified carbon fibre microelectrodes offer substantial improvement in voltammetric sensitivity and selectivity towards epinephrine (EP). The poly(neutral red) film was electropolymerized by cycling the potential between -0.8 V and +0.8 V. The anodic stripping voltammetric response for EP was found to be dependent on accumulation time and potential. By using a poly(neutral red) film modified carbon fibre microelectrode with a 1 min preconcentration at -1.2 V in biological phosphate buffer solution (pH=7.4), a good linear relationship between the anodic stripping peak currents and EP concentrations was obtained in the range of 2.0×10 -7 ￣ 2.0×10 -5 mol/L. The detection limit was up to 9.0 ×10 -8 mol/L. Moreover, 400 times higher concentrations of vitamin C did not interfere with the measurement of EP. This method was used for determining EP concentrations in epinephrine hydrochloride injection solution with satisfactory results.