Effect of ethanolic extract of Physalis minima on lowering blood pressure in DOCA-salts hypertensive rat models

作     者：Nur PERMATASARI Dian NUGRAHENNY Saifurrohman 

作者机构：Department of Pharmacology Faculty of Medicine Brawijaya University Indonesia Department of Internal Medicine Faculty of Medicine Brawijaya University Indonesia 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2015年第29卷第S1期

页      面：33-33页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by Republic of Indonesia through the Ministry of National Education Health Professional Education Quality(HPEQ Project)IBRD LOAN NO.7737-IND 

主　　题：physalis minima blood pressure endothelial cell st 

摘      要：OBJECTIVE To explore the effect of ethanolic extract of Physalis minima on lowering blood pressure in the DOCA-salts hypertensive *** To produce hypertension,male rats were induced DOCA at dose of 10mg·kg-1 *** weekly and 0.9% NaCl in drinking water ad libitum for six *** ethanolic extract of Physalis minima were given at dose of 500,1500 and 2500mg·kg-1,respectively for *** completion of treatment schedule,systolic blood pressure was evaluated using animal blood pressure *** serum nitric oxide levels was measured using the ELISA *** activity and MDA level were determined *** dysfunction was determined by acetylcholine-induced vasorelaxation studies on isolated rat *** The extract decreased systolic blood pressure significantly(P0.001)in hypertensive *** addition,the extract also suppressed the production of MDA and restored SOD activity to normal *** was a reduced relaxation response to acetylcholine in isolated aortic rings and serum NO level from hypertensive rats that were reversed by *** Physalis minima can lower blood pressure in hypertensive rats and its mechanism may be through the improvement of endothelial function due to the decrease of stress oxidative.