Targeting Gene-Virotherapy for Cancer
Targeting Gene-Virotherapy for Cancer作者机构：Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China Xinyuan Institute of Medicine and Biotechnology School of Life Sciences Zhejiang Sci-Tech UniversityHangzhou 310018 China
出 版 物：《Acta Biochimica et Biophysica Sinica》 (生物化学与生物物理学报(英文版))
年 卷 期：2005年第37卷第9期
页 面：581-587页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：cancer therapy gene targeting viral vector targeting gene-virus
摘 要：Gene therapy and viral therapy for cancer have therapeutic effects,but there has been nosignificant breakthrough in these two forms of ***,a new strategy called “targeting gene-virotherapy,which combines the advantages of gene therapy and viral therapy,has been *** therapy has stronger antitumor effects than either gene therapy or viral therapy.A tumor-specific repli-cative adenovirus vector ZD55 (E1B55KD deleted Adv.)was constructed and various single therapeuticgenes were inserted into ZD55 to form *** are the targeting gene-virotherapy *** showed that a single gene was not effective in eliminating the tumor mass,and therefore twogenes were separately inserted into *** strategy is called “targeting dual gene-virotherapy(withPCT patent).Better results were obtained with this strategy,and all the xenograft tumor masses were com-pletely eliminated in all mice when two suitable genes producing a synergetic or compensative effect ***-six papers on these strategies have been published by researchers in our ***,an adenoviral vector with two targeting promoters harboring two antitumor genes has beenconstructed for cancer *** results have been obtained with this adenoviral vector and anotherpatent has been applied *** antitumor strategy can be used to kill tumor cells completely with minimumdamage to normal cells.
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