Genetic diversity of HCV among various high risk populations(IDAs,thalassemia,hemophilia,HD patients) in Iran

作     者：Rafiei A Darzyani Azizi M Taheri S Haghshenas MR Hosseinian A Makhlough A 

作者机构：Molecular and Cell Biology Research Center.Faculty of MedicineMazandaran University of Medical Sciences18KM Khazar BlvdKhazar Sq.SariIran Department of Internal MedicineFaculty of MedicineMazandaran University of Medical SciencesSari.Iran Nephrology WardDepartment of Internal MedicineFaculty of MedicineMazandaran University of Medical SciencesSari.Iran 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2013年第6卷第7期

页      面：556-560页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：financially supported by Molecular and Cell Biology Research Center Mazandaran University of Medical Sciences with grant number MCBRC-MAZUMS-89-52 

主　　题：HCV Thalassemia Hemophilia Hemodialysis Intravenous drug addicts Iran 

摘      要：Objective:To determine the patterns of distribution of HCV genotypes among high risk population in north of ***:A cross-sectional study was conducted on 135 HCV RNA-positive high risk individuals including thalassemia,hemophilia,patients under hemodialysis and intravenous drug *** genotypes were determined based on amplification with type-specific primers ***:Among the 187 anti-HCV positive samples,only 135 (72.2%)gave HCV-RNA *** all,the most identified HCV type was genotype 3a(51.1%) followed by 1a(27.4%),1b(8.2%).Sixteen(11.9%)out of 135 HCV RNA-positive participants have infected with more than one genotype or subtypes as follow:1a/1b in 11(8.2%),2/3a in 3 (2.2%),and 1a/1b/3a in 2(1.5%).Stratification of participants revealed that HCV subtype 3a was more prominent in thalassemia,hemophilia and HD patients but 1a and 1b were frequent in intravenous drug ***:This study is the first report on HCV genotypes among Iranian subjects with different exposure categories resided in *** genotype 3a was found to be the most frequent genotype in thalassemia,hemophilia,and hemodialysis patients but not in *** the addiction age is decreasing in Iran and a lot of addicts are *** might change the subtype pattern of HCV in general population.