Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model

作     者：Wenrong Xu Weixin Fan Kun Yao 

作者机构：Department of Dermatology the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Microbiology and Immunology Nanjing Medical University Nanjing Jiangsu 210029 China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2012年第26卷第5期

页      面：372-380页

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.30571678 and No.30771947) the Natural Science Foundation of Jiangsu Province(No.BK2007248) 

主　　题：cyclosporine A (CsA) hair follicle mouse vibrissae 

摘      要：Hypertrichosis is one of the most common side effects of systemic cyclosporine A *** has been previously shown that cyclosporine A induces anagen and inhibits catagen development in *** the present study,to explore the mechanisms of cyclosporine A,we investigated the effects of cyclosporine A on hair shaft elongation,hair follicle cell proliferation,apoptosis,and mRNA expression of selected growth factors using an organ culture model of mouse *** this model,cyclosporine A stimulated hair growth of normal mouse vibrissae follicles by inhibiting catagen-like development and promoting matrix cell *** addition,cyclosporine A caused an increase in the expression of vascular endothelial growth factor（VEGF）,hepatocyte growth factor（HGF）,and nerve growth factor（NGF）,and inhibited follistatin *** findings provide an explanation for the clinically observed effects of cyclosporine A on hair *** mouse vibrissae organ culture offers an attractive model for identifying factors involved in the modulation of hair growth.