A novel peptide specifically binding to VEGF receptor suppresses angiogenesis in vitro and in vivo
作者机构：Department of OphthalmologyShanghai General HospitalShanghai Jiaotong University School of MedicineShanghaiChina Key Laboratory for NeuroInformation of Ministry of EducationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina Chengdu Nuoen BiotechnologiesLTDChengduChina Center for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengduChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2017年第2卷第1期
页 面：222-228页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：The study is supported by National Natural Science Foundation of China(61571095) Program for New Century Excellent Talents in University(NCET-12-0088) the Fundamental Research Funds for the Central Universities(ZYGX2015Z006)
主 题：angiogenesis vivo VEGFR
摘 要：Vascular endothelial growth factor(VEGF),one of the most important angiogenic factors,plays an essential role in both physiological and pathological angiogenesis through binding to VEGF receptors(VEGFRs).Here we report a novel peptide designated HRHTKQRHTALH(peptide HRH),which was isolated from the Ph.D.-12 phage display library using VEGFR-Fc fusion protein as the *** peptide was found to dose-dependently inhibit the proliferation of human umbilical vein endothelial cells stimulated by *** anti-angiogenesis effect of the HRH peptide was further confirmed in vivo using the chick chorioallantoic membrane assay,which was also ***,peptide HRH was proved to inhibit corneal neovascularization in an alkali-burnt rat corneal model and a suture-induced rat corneal *** together,these findings suggest that the HRH peptide can inhibit angiogenesis both in vitro and in ***,the HRHTKQRHTALH peptide might be a promising lead peptide for the development of potential angiogenic inhibitors.
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