Kinetics of Serum and Local Leukotriene B<sub>4</sub>Response in Experimental Intravaginal Trichomoniasis by <i>T. vaginalis</i>Isolates from Symptomatic and Asymptomatic Women

作     者：Amany M. Eida Omima M. Eida Ahmed Saied Salem 

作者机构：Department of Parasitology Faculty of Medicine Suez Canal University Ismailia Egypt Department of Pathology Faculty of Medicine Al-Azhar University Cairo Egypt 

出 版 物：《Advances in Infectious Diseases》 (传染病进展（英文）)

年 卷 期：2015年第5卷第1期

页      面：37-47页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Trichomoniasis Clinical Isolates Experimental Study Pathogenesis Immune Response Leukotriene B4 

摘      要：Trichomoniasis is most common sexually transmitted disease caused by T. vaginalis. The clinical manifestation varies from severe manifestation to asymptomatic condition. However, the exact virulence markers led to varied symptomatology was not well clarified. The role of leukotriene B4 (LTB4) in the pathogenesis of many parasitic diseases has been reported. The present study reports the leukotriene B4 levels on different days post infection (3rd, 7th, 14th, 21st and 28th d.p.i.) in serum and vaginal washes (VWs) and vaginal tissues of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. A significant increase in LTB4 was observed on the 3rd to 28th d.p.i. in serum and VWs of mice infected with T. vaginalis isolates from asymptomatic as compared to symptomatic women. The present study also reports the histopathological changes of the posterior vaginal fornix’s and upper portion of the vagina of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. The results show that there are no significant differences between symptomatic and asymptomatic isolates regarding histopathological changes.