A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI

作     者：Kishor S. Jain Swapnil. K. Chaudhari Nikhil S. More Kapil D. More Sachin A Wakedkar M. K. Kathiravan 

作者机构：不详 

出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)

年 卷 期：2011年第1卷第2期

页      面：47-52页

学科分类：07[理学] 0703[理学-化学] 

主　　题：Microwave Assisted Organic Synthesis (MAOS) 2-Amino-5-Cyano-2 6-Disubstitutedpyrimidines Α-Cyanoketene S S-Acetals 

摘      要：Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.