An integrated analysis of mRNA-miRNA transcriptome data revealed hub regulatory networks in three genitourinary cancers

作     者：Mian LIU Xumeng ZHANG 

作者机构：Center for Reproductive MedicineDepartment of Obstetrics and GynecologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515P.R.C State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510006P.R.C 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2017年第41卷第1期

页      面：19-26页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Genitourinary cancers Differentially expressed genes Differentially expressed miRNAs Hub genes 

摘      要：Bladder,kidney,prostate and testicular carcinoma are the top four genitourinary cancers in *** we analyzed mRNA and miRNA expression profiles of carcinomas of the bladder(TCC),kidney(ccRCC)and testis(TGCT)to uncover their specific regulatory *** gene expression profiles of GSE31617 were downloaded from GEO database,which contained 27 samples,including 10 TCC,7 TGCT and 10 *** up-and downregulated differentially expressed genes(DEGs)and differentially expressed microRNAs(DEmiRNAs)of each cancer were selected and target genes of DEmiRNAs were *** interaction network of the shared genes and target genes of DEmiRNAs of each cancer was predicted by STRING and constructed by *** each cancer,we build regulatory networks of hub genes selected and conducted GO analysis of enriched ***,we chose four hub genes(SALL4,RHEB,CDC42 and TNN)for survival analysis in OncoLnc database,and they all had effects on the survival rate of another genitourinary cancer-kidney renal clear cell carcinoma(KIRC).In conclusion,the present study indicated that the identified hub genes promote our understanding of molecular mechanisms underlying the development of three genitourinary cancers,and might be used as molecular targets and diagnostic biomarkers for the treatment of them.