The Role of Leptin in Cancer Pathogenesis
The Role of Leptin in Cancer Pathogenesis作者机构：Oncology Unit GPP Sotiria General Hospital Athens School of Medicine Athens Greece
出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)
年 卷 期：2013年第4卷第2期
页 面：640-650页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Leptin Adipokines Cancer Systemic Inflammation
摘 要：Leptin is a hormone produced and secreted by adipose tissue. It is a member of adipokine family with a principal role in body weight regulation. It is reported that low brain leptin levels enhance the activity of hypothalamic orexigenic signals promoting feeding and suppressing energy expenditure and vice versa. Moreover, leptin via its three receptors participates in multiple neuroendocrine loops regulation. Serum leptin levels are positively associated with BMI (Body Mass Index) and whilst interact not only with other cytokines but also with serum insulin and cortisol levels. The aim of the present review is to study the role of leptin in carcinogenesis and its implications in cancer-related systemic inflammation.
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