Mapping It out: A Novel Signaling Pathway Linking Aβ-PrP<sup>c</sup>-Fyn Complex to Cognitive Impairment in Alzheimer’s Disease
Mapping It out: A Novel Signaling Pathway Linking Aβ-PrP<sup>c</sup>-Fyn Complex to Cognitive Impairment in Alzheimer’s Disease作者机构：Department of Neuroscience Duke University Durham NC 27708 USA Shanghai Key Laboratory of Signaling and Disease Research School of Life Science Shanghai 200092 China
出 版 物：《Advances in Alzheimer's Disease》 (阿尔茨海默氏病研究进展（英文）)
年 卷 期：2014年第3卷第1期
页 面：20-23页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Alzheimer’s PrPc Aβ Fyn Tau Microtubule
摘 要：Understanding the signaling cascade that leads to the rapid memory and cognitive breakdown in Alzheimer’s disease is the key to finding a potential treatment method for the disease. Recently, Larson et al. connect the roles of major proteins implicated in the disease progression and propose targeting of cellular prion protein (PrPc) as a way of someday rescuing synaptic plasticity in humans with Alzheimer’s, as it has been done on mice.
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