Prognostic Significance of Apoptosis Regulators in B-Cell Chronic Lymphocytic Leukemia
Prognostic Significance of Apoptosis Regulators in B-Cell Chronic Lymphocytic Leukemia作者机构：Clinical Pathology Department Faculty of Medicine Zagazig University Zagazig Egypt Medical Oncology Department Faculty of Medicine Zagazig University Zagazig Egypt Clinical Oncology & Nuclear Medicine Department Faculty of Medicine Zagazig University Zagazig Egypt Internal Medicine Department Faculty of Medicine Zagazig University Zagazig Egypt
出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)
年 卷 期：2017年第8卷第4期
页 面：360-385页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Myeloid Cell Leukemia 1 B-Cell Lymphoma 2 BAX B-Cell Chronic Lymphocytic Leukemia
摘 要：Background: High levels of MCL-1 and BCL-2 proteins have been found in Chronic Lymphocytic Leukemia (CLL), and inversely correlated with response to treatment. BCL-2/Bax ratio is the main director of apoptosis in CLL. The study aimed to clarify the prognostic role of MCL-1, BCL-2 and BCL-2/ Bax ratio in B-CLL. Patients & method: Estimation of MCL-1, BCL-2 and Bax expressions by a flow cytometry in 45 B-CLL patients and the prognostic value of these markers were correlated with other well-known established prognostic markers and treatment response. Results: MCL-1 was expressed in 60% of cases while BCL-2 was expressed in 82.2% of cases. MCL-1 expression was significantly high in male gender, short lymphocyte doubling time (LDT), and high expression of CD 38 (p β2M, CD38 expression), low ZAP-70 expression, splenomegaly and higher Rai stage were significantly increased in patients with high expression of BCL-2 (p β2M, high C-D38 expression, low ZAP-70 expression, the poor cytogenetic and splenomegaly in patients with high expression of BCL-2/ Bax ratio (p In conclusion: MCL-1, BCL-2 expressions and BCL-2/Bax ratio could be useful potential predictive and prognostic markers in B-CLL.
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