Optimum Kinetic Parameters of Mefenamic Acid Crystallization by PBM
甲芬那酸的结晶动力学参数的最佳PBM作者机构：Engineering FacultyChemical Engineering DepartmentEge UniversityBornovaTurkey.
出 版 物：《Journal of Crystallization Process and Technology》 (结晶过程及技术期刊（英文）)
年 卷 期：2012年第2卷第3期
页 面：81-95页
主 题：Industrial Crystallization Recrystallization Mefenamic Acid Crystal Growth from Solutions Crystallization in Solutions of Macromolecules Computer Modeling Simulation
摘 要：Mefenamic acid (MA) is a high-dose, anti-inflammatory, analgesic agent that is widely prescribed for pain related to menstrual disorders. It has some negative properties, such as a high hydrophobicity with a propensity to stick to surfaces, and possess great problems during granulation and tableting. Crystallization kinetics was investigated for mefenamic acid. Availability of data on the kinetics of crystal growth is very important for the development and operation of industrial crystallisation processes. The experiments for the measurement of crystal growth kinetics were carried out using the desupersaturation curve technique based on the measurement of the solution concentration versus time in a seeded isothermal batch experiment. To predict the optimum parameters (b, kb, g, kg) for the nucleation and growth kinetics from the desupersaturation curve obtained, the Population Balance Modelling was used and solved by the method of moments. The initial values for the optimisation problem were estimated by using the approach developed by Garside et al. (1982) [1].
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