Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone
Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone作者机构：Department of Hematology Eiju General Hospital Tokyo Japan Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan
出 版 物：《Open Journal of Pathology》 (病理学期刊（英文）)
年 卷 期：2012年第2卷第4期
页 面：155-158页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Plasmacytoma Testis Lenalidomide
摘 要：We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed with IgG-λ-type multiple myeloma and treated with melphalan and prednisolone plus bortezomib, achieving a complete remission. Four months later, his left scrotum began to swell and pathological investigation of a needle biopsy specimen revealed proliferation of plasma cells expressing IgG-λ, confirming myeloma recurrence. However, bone marrow aspiration samples showed no significant increase in myeloma cells and there was no skewed deviation of the K/λ ratio on flow-cytometric analysis. The extramedullary tumors disappeared completely soon after treatment with lenalidomide plus dexamethasone, and the patient was judged to be in very good partial remission based on negative M-protein results by serum immunoelectrophoresis. This is the first report, to our knowledge, describing complete disappearance of a testicular plasmacytoma after treatment with lenalidomide as the key-drug.
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