Radiation-Induced Spinal Glioblastoma Multiforme: A Rare Complication in the Management of Head and Neck Cancer

作     者：Andrew W. Ju H. Ian Robins M. Shahriar Salamat Allison M. Grayev Steven P. Howard Andrew W. Ju;H. Ian Robins;M. Shahriar Salamat;Allison M. Grayev;Steven P. Howard

作者机构：Department of Radiation Oncology Brody School of Medicine East Carolina University Greenville NC USA Department of Human Oncology School of Medicine and Public Health University of Wisconsin Madison WI USA Department of Medicine School of Medicine and Public Health University of Wisconsin Madison WI USA Department of Neurology School of Medicine and Public Health University of Wisconsin Madison WI USA Department of Pathology School of Medicine and Public Health University of Wisconsin Madison WI USA Department of Radiology School of Medicine and Public Health University of Wisconsin Madison WI USA 

出 版 物：《International Journal of Otolaryngology and Head & Neck Surgery》 (耳鼻喉（英文）)

年 卷 期：2016年第5卷第6期

页      面：233-241页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Central Nervous System Spinal Cord Glioblastoma Multiforme Radiation Induced Head and Neck Cancer 

摘      要：Background: Radiation-induced gliomas of the spinal cord are rare late complications of spinal cord irradiation that typically occur in patients treated at younger ages. Aim: Raise awareness of radiation induced high grade gliomas with a case presentation and a review of the literature. Case Presentation: A 50-year-old male with Stage IVA squamous cell carcinoma of the oropharynx was treated with external beam radiotherapy with a complete response. Seven years later, he presented with a cervical spinal cord mass on MRI. An open biopsy was performed. Pathology revealed an intramedullary WHO grade IV astrocytoma, (i.e., glioblastoma multiforme) of the cervical spine that fulfilled the criteria for a radiation-induced malignancy. Conclusions : Review of the literature suggests that radiation-induced gliomas tend to be high grade and may occur at the periphery of an irradiated field. Radiation-induced gliomas of the spinal cord are a serious complication of radiotherapy that may occur in older patients with head and neck cancers, but are so rare that it should not affect treatment decisions.