Photoisomerization of Provitamin D in Hydrogel Matrix

作     者：I. P. Terenetskaya Yu. M. Samchenko T. N. Orlova N. A. Pasmurceva P. S. Kapinos I. E. Boldeskul Z. R. Ulberg 

作者机构：Institute of Physics NAS Ukraine Prospekt Nauki Kyiv Ukraine Ovcharenko Institute of Biocolloid Chemistry NAS Ukraine Acad. Vernadsky Blvd. Kyiv Ukraine 

出 版 物：《Soft》 (软金属（英文）)

年 卷 期：2013年第2卷第2期

页      面：8-12页

学科分类：07[理学] 0703[理学-化学] 

主　　题：Hydrogels Provitamin D Photoisomerization UV Biodosimeter 

摘      要：Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)- and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D3(7-dehydrocholesterol) and D2(ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active ‘antirachitic’ UV radiation.