Aqueous-Phase, Palladium-Catalyzed Suzuki Reactions under Mild Conditions
Aqueous-Phase, Palladium-Catalyzed Suzuki Reactions under Mild Conditions作者机构：School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China Shanghai Key Laboratory of Chemical Biology Institute of Pesticides & Pharmaceuticals East China University of Science and Technology Shanghai China
出 版 物：《Green and Sustainable Chemistry》 (绿色与可持续化学（英文）)
年 卷 期：2013年第3卷第4期
页 面：1-5页
主 题：Suzuki Reaction Ionic Liquid-Supported Diols Phosphine-Free Ligands
摘 要：Water-soluble ionic liquid-supported diols have been used as phosphine-free ligands in Suzuki couplings of aryl idides/bromides/chlorides under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-mehyl) propane-1,3-diol hexafluorophosphate (4) in combination with palladium (II) salts gave the most significant catalyst. Suzuki couplings of aryl iodides/bromides occurred efficiently at room temperature in water/acetonitrile. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. The catalyst PdCl2-4 was recycled five times in Suzuki couplings in water before catalyst activity began to significantly drop. The average yield of five cycles was 95% per cycle.
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