Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering

作     者：Xianshuo CAO Jun WANG Min LIU Yong CHEN Yang CAO Xiaolong YU 

作者机构：College of Materials and Chemical Engineering Hainan University Haikou 570228 China College of Ocean Hainan University Haikou 570228 China 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2015年第9卷第4期

页      面：405-412页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 080104[工学-工程力学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：Acknowledgements The authors acknowledge the financial support of the International Science Cooperation Program of Hainan (Grant Nos. KJHZ2014-19 and KJHZ2015-02). This work was also financially supported by the National Natural Science Foundation of China (NSFC Grant Nos  51162006  51362009 and 51361009) and the Key Science & Technology Project (ZDXM2015118) 

主　　题：chitosan (CS) collagen (COL) montmorillonite (MMT) sodium dodecylsulfate (SDS) 

摘      要：A novel composite scaffold based on chitosan-collagenlorganomontmo- rillonite （CS-COL/OMMT） was prepared to improve swelling ratio, biodegradation ratio, biomineralization and mechanical properties for use in tissue engineering applications. In order to expend the basal spacing, montmorillonite （MMT） was modified with sodium dodecyl sulfate （SDS） and was characterized by XRD, TGA and FTIR. The results indicated that the anionic surfactants entered into interlayer of MMT and the basal spacing of MMT was expanded to 3.85 nm. The prepared composite scaffolds were characterized by FTIR, XRD and SEM. The swelling ratio, biodegradation ratio and mechanical properties of composite scaffolds were also studied. The results demonstrated that the scaffold decreased swelling ratio, degradation ratio and improved mechanical and biomineralization properties because of OMMT.