Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review

作     者：Shang-Li Ji Shi-Bo Tang 

作者机构：Aier Eye Institute Aier School of OphthalmologyCentral South University 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2019年第12卷第1期

页      面：152-160页

核心收录：

学科分类：10[医学] 

基　　金：Supported by "555 Talent Plan" Grant from the Changsha National High-Tech Industrial Development Zoom 

主　　题：glaucoma retinal ganglion cells induced pluripotent stem cells differentiation 

摘      要：Glaucoma is a common optic neuropathy that is characterized by the progressive degeneration of axons and the loss of retinal ganglion cells(RGCs). Glaucoma is one of the leading causes of irreversible blindness worldwide. Current glaucoma treatments only slow the progression of RGCs loss. Induced pluripotent stem cells(iPSCs) are capable of differentiating into all three germ layer cell lineages. iPSCs can be patient-specific,making iPSC-derived RGCs a promising candidate for cell replacement. In this review, we focus on discussing the detailed approaches used to differentiate iPSCs into RGCs.