Colorectal Cancer: Epidemiological Study, Clinical, Histological and Immunohistochemistry Examination in Patient of West Algeria

作     者：F. Z. Bensaada H. Ould Cadi T. Sahraoui F. Z. El Kebir 

作者机构：Laboratory of Biology of Development and Differanciation Department of Biology Faculty of Natural Science and Life University of Oran 1 (Ahmed Benbella) Oran Algeria 

出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)

年 卷 期：2017年第8卷第1期

页      面：26-36页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Adenocarcinoma Colorectal Cancer (CRC) Cytokeratin (7 20) 

摘      要：Colorectal cancer (CRC) is significant publichealth problem in rich countries of the world, because of its frequency and mostly because of its severity. Our aim was to improve histologic diagnosis of malignancy with topographic coloration (HE) and cytokeratins 7, 20 immuno-labeling. The risk for colorectal cancer incease with age, but in our series, 10% of colorectal cancer exist in patients younger than 40 years old. In histological study, adenocarcinoma represented 100% and the evaluation for stage of disease showed that the most dominant isstage IV (32.6%). In our trial, we found that cytokeratins 7 and 20 immunoreactivity in colorectal adenocarcinoma are often positive for cytokeratin-20 and most of time negative for cytokeratin-7.