Vitamin D deficiency in critically ill patients with traumatic injuries

作     者：Roland N.Dickerson Jonathan R.Van Cleve Joseph M.Swanson George O.Maish III Gayle Minard Martin A.Croce Rex O.Brown 

作者机构：Department of Clinical PharmacyUniversity of Tennessee Health Science Center881 Madison AvenueSuite 345Memphis 38163TNUSA Department of SurgeryUniversity of Tennessee Health Science Center910 Madison Avenue2nd FloorMemphis 38163TNUSA 

出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)

年 卷 期：2016年第4卷第4期

页      面：307-315页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Vitamin D Deficiency Depletion Trauma Injury Parenteral nutrition Enteral nutrition African-American Obesity 

摘      要：Background:Vitamin D depletion has been associated with increased rate of infections,lengthened hospital stay,and worsened mortality for critically ill *** purpose of this study was to evaluate the prevalence and variables associated with vitamin D deficiency in critically ill patients with severe traumatic ***:Critically ill adult patients admitted to the trauma intensive care unit(ICU)between June 2013 and June 2014,referred to the nutrition support service for enteral or parenteral nutrition,and had a serum 25-hydroxyvitamin D(25-OH vitamin D)concentration determination were retrospectively *** were stratified as vitamin D sufficient,insufficient,deficient,or severely deficient based on a 25-OH vitamin D concentration of 30–80,20–29.9,13.1–19.9,and≤13 ng/mL,***:One hundred and twenty-one patients out of 158(76%)patients were vitamin D deficient or severely ***-one patients(20%)were insufficient and 6(4%)had a normal 25-OH vitamin D concentration.25-OH vitamin D was determined 7.5±5.1 days after ICU ***-Americans had a greater proportion of patients with deficiency or severe deficiency compared to other races(91 versus 64%,P=0.02).Penetrating gunshot or knife stab injury,African-American race,and obesity(elevated body mass index)were significantly associated with vitamin D deficiency or severe deficiency:OR 9.23(1.13,75.40),4.0(1.4,11.58),and 1.12(1.03,1.23),P0.05,***:The majority of critically ill patients with traumatic injuries exhibit vitamin D deficiency or severe *** injuries,African-American race,and obesity are significant risk factors for *** of injury,extent of inflammation(elevated C-reactive protein concentration),or hospital admission during the winter season did not significantly influence the prevalence of vitamin D deficiency.