Common Preconditions for Safe Phage Therapy of <i>Pseudomonas aeruginosa</i>Infections
Common Preconditions for Safe Phage Therapy of <i>Pseudomonas aeruginosa</i>Infections作者机构：Mechnikov Research Institute for Vaccines & Sera RAMS Moscow Russia
出 版 物：《Advances in Microbiology》 (微生物学（英文）)
年 卷 期：2014年第4卷第12期
页 面：766-773页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Phage Therapy Safety Measures Pseudomonas aeruginosa
摘 要：One of the approaches to the treatment of infections caused by multiply-(MDR) or extra drug- resistant (XDR) pathogenic strains may be application of bacterial viruses (bacteriophages)— phage therapy. Results of a long, but quite limited use of phage therapy in several Eastern European countries, as well as experiments on animal models in Western countries support the possibility to use phage therapy. However, given the role of phages in the evolution of bacterial pathogens, it is necessary to discuss and evaluate negative consequences of mass introduction of phage therapy, as the measures necessary for its safe use. We discuss some actions in case of transiting to world-wide use of phage therapy with purpose to prolong the active life of phage therapy and to diminish possible complications.
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