Model of Multi-Source Nanonetworks for the Detection of BRCA1 DNA Alterations Based on LSPR Phenomenon

作     者：Renato Iovine Valeria Loscrí Sara Pizzi Richard Tarparelli Anna Maria Vegni 

作者机构：Department of Engineering University of Roma Tre Rome Italy Dipartimento di Ingegneria dell’Informazione delle Infrastrutture e dell’Energia Sostenibile (DIIES) Mediterranea University of Reggio Calabria Reggio Calabria Italy Dipartimento di Ingegneria Informatica Modellistica (DIMES) Elettronica e Sistemistica University of Calabria Cosenza Italy 

出 版 物：《Advances in Nanoparticles》 (纳米粒子（英文）)

年 卷 期：2013年第2卷第4期

页      面：301-312页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Nanoparticles Nanonetworks LSPR DNA Alterations BRCA1 

摘      要：In this paper, we present a multi-source nanonetwork model for biomedical diagnosis applications, based on the Localized Surface Plasmon Resonance by different shape gold nanoparticles (i.e., cylinder, cube, and rod). We present the process of multi-source emission, diffusion, and reception of nanoparticles, based on the ligand/receptor binding. Then, a multi-detection process of DNA alterations is accomplished when nanoparticles are captured at the receiver. The colloidal particles are selectively functionalized with specific splice junctions of gene sequences to reveal simultaneously different alteration that could be associated to an early disease condition. Particularly, full-wave simulations have been carried out for the multi-detection of alternative splice junctions of breast cancer susceptibility gene 1. The proposed application is verified through numerical results and expressed in terms of Extinction-Cross Section, in the case of synchronous and asynchronous nanoparticles detection. We show that the proposed approach is able to detect DNA alterations, based on a selective nanoparticle reception process.