J Wave Syndromes： A Decade of Progress

作     者：Guo-Liang Li Lin Yang Chang-Cong Cui Chao-Feng Sun Gan-Xin Yan Li Guo-Liang;Yang Lin;Cui Chang-Cong;Sun Chao-Feng;Yan Gan-Xin

作者机构：Department of Cardiovascular Medicine The First Affiliated Hospital Xi'an Jiaotong University College of Medicine Xi'an Shaanxi 710061 China Department of Cardiovascular Medicine Lankenau Medical Center and Lankenau Institute of Medical Research PA USA Department of Cardiovascular Medicine Jefferson Medical College of Thomas Jefferson University PA USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第7期

页      面：969-975页

核心收录：

学科分类：090603[农学-临床兽医学] 050302[文学-传播学] 05[文学] 09[农学] 0906[农学-兽医学] 0503[文学-新闻传播学] 

基　　金：Sharpe-Strumia Research Foundation  and National Natural Science Foundation of China (No. 81400258  81370289  81270236) 

主　　题：Brugada Syndrome Early Repolarization Syndrome J Wave Syndromes ST-Segment Elevation Myocardial Infarction Transient Outward Potassium Current 

摘      要：Objective： The objective was to provide a brief history of J wave molecular, ionic, cellular mechanisms, and clinical features. We will clinical research for J wave syndromes. syndromes and to summarize our current understanding of their also discuss the existing debates and further direction in basic and Data Sources： The publications on key words of＂J wave syndromes＂, ＂early repolarization syndrome （ERS）＂, ＂Brugada syndrome （BrS）＂ and ＂ST-segment elevation myocardial infarction （STEMI）＂ were comprehensively reviewed through search of the PubMed literatures without restriction on the publication date. Study Selection： Original articles, reviews and other literatures concerning J wave syndromes, ERS, BrS and STEMI were selected. Results： J wave syndromes were firstly defined by Yah et al. in a Chinese journal a decade ago, which represent a spectrum of variable phenotypes characterized by appearance of prominent electrocardiographic J wave including ERS, BrS and ventricular fibrillation （VF） associated with hypothermia and acute STEMI. J wave syndromes can be inherited or acquired and are mechanistically linked to amplification of the transient outward current （I ）-mediated J waves that can lead to phase 2 reentry capable of initiating VF. Conclusions： J wave syndromes are a group of newly highlighted clinical entities that share similar molecular, ionic and cellular mechanism and marked by amplified J wave on the electrocardiogram and a risk of VF. The clinical challenge ahead is to identify the patients with J wave syndromes who are at risk for sudden cardiac death and determine the alternative therapeutic strategies to reduce mortality.