Relationship between bone mineral density, coronary risk factors, C-reactive protein, and Insulin growth factor in frail elderly
Relationship between bone mineral density, coronary risk factors, C-reactive protein, and Insulin growth factor in frail elderly作者机构：Clinical Pathology Department Faculty of Medicine Ain Shams University Cairo Egypt Geriatrics and Gerontology Department Faculty of Medicine Ain Shams University Cairo Egypt Geriatrics and Gerontology Department Faculty of Medicine Ain Shams University Cairo Egypt
出 版 物：《Advances in Aging Research》 (老年问题研究（英文）)
年 卷 期：2014年第3卷第1期
页 面：43-47页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Frailty Bone Mineral Density Coronary Risk Factors
摘 要：Objective: This study aimed to explore the relation between bone mineral density (BMD), inflammation, coronary risk factors, and Insulin growth factor (IGF) in frail elderly. Design: A casecontrol study. Setting: Ain Shams University Hospital Cairo, Egypt. Participants: Ninety aged 60 years and above;sixty frail (30 males and 30 females;mean age 70.03 ± 8.10) and thirty matched controls (15 males and 15 females;mean age 69.07 ± 5.93). Measurements: History, examination, comprehensive geriatric assessment, measurement of BMD, and laboratory investigations including;high sensitivity C-reactive protein (hs-CRP) glycated haemoglobin, IGF, lowdensity lipoprotein (LDL), high-density lipoprotein, total cholesterol, and triglycerides. Results: The frail group had significantly lower levels of triglycerides and LDL, hs-CRP and glycated haemoglobin levels were significantly higher (P 0.001), and BMD and IGF levels were significantly lower when compared with the control group (P 0.00*, P = 0.05) respectively. We also found that BMD had a significant positive linear correlation with IGF and negative correlation with age. Conclusion: Frailty was associated with low BMD, lower triglycerides & LDL levels, and higher hsCRP levels. A borderline significance was found between IGF levels and frailty. A positive correlation was found between BMD and IGF in frail.
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