GnRH Antagonist Protocol: Is It Optimal for All Patients of Different Ages Undergoing <i>In Vitro</i>Fertilization and Embryo Transfer?

作     者：Weijie Xing Haiyan Lin Qingxue Zhang 

作者机构：Center for Reproductive Medicine The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China Center for Reproductive Medicine Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangzhou China 

出 版 物：《Advances in Sexual Medicine》 (性医学进展（英文）)

年 卷 期：2017年第7卷第4期

页      面：153-160页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：GnRH Agonist GnRH Antagonist IVF-ET 

摘      要：Background: To assess the effect of these two protocols in patients of different ages. Methods: 1923 in vitro fertilization and embryo transfer (IVF-ET) cycles were divided into two groups: a GnRH-ant protocol group and GnRH-a long protocol group, and then every group were subdivided into four age ranges. The general materials and IVF outcomes were compared. Results: The incidence of OHSS fluctuated from 0% to 2.37% with GnRH-ant protocol, which was significantly lower than another (P P Conclusion: The antagonist protocol should be considered in patients with a high ovarian response (e.g., PCOS patients) to avoid OHSS. Older patients (35 years) could be treated with the antagonist protocol.